Biomarkers associated with vulnerable plaques

Abstract Background Cardiovascular heart disease is the leading cause of mortality worldwide, with rupture or thrombosis an atherosclerotic plaque being main reason behind acute coronary syndrome. It has already been established that morphology plaques determine their stability. A lipid rich lesion a thin fibrous cap more prone to compared solid lesions. In PROSPECTII study we used Near infrared spectroscopy (NIRS) and Intravascular ultrasound (IVUS) identify in arteries; NIRS-derived core burden index (LCBI) IVUS-derived (PB) identified caused adverse cardiovascular events. Purpose Our aim find biomarkers associated LCBI PB, understand development vulnerable plaques. Methods 902 patients were enrolled this after successful percutaneous intervention (PCI). combined NIRS-IVUS catheter was then analyze approximately 200m arteries. Blood samples for biomarker analysis taken before PCI procedure plasma levels 182 proteins assessed using novel method measuring proximity extension assay. Adjusted linear regression models calculated between outcomes interest, followed by false discovery rate (FDR) correction. Results We found 24 28 cut off two tailed P value <0.05. An overlap 8 could be seen groups. After adjusting values FDR, Angiopoeitin like 3 (ANGPTL3) retained its association LCBI, Interleukin 18 receptor 1 (IL18R1) colony stimulating factor (CSF-1) burden. Conclusion able different patterns ANGPTL3 shown only have not lesions which further supports role Funding Acknowledgement Type funding sources: Private company. Main source(s): Abbott Vascular, Infraredx, The Medicines Company